The hidden conversation between your muscles and your brain: How strength training rewires the mind Strength training directly boosts brain health by releasing irisin and myokines like IGF-1, which travel from muscles to the brain – improving memory, verbal fluency and neuroplasticity. A 12-week study found that while resting irisin levels didn’t rise, the repeated signals from each workout – not constant hormone elevation – produced measurable cognitive improvements in older adults. Leg-focused exercises such as squats and step-ups yield some of the strongest cognitive benefits, helping preserve brain structures tied to learning and executive function. Just two to three…

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