Study Links Senolytic Drugs to Reduced Cholesterol in Brain Support Cells, Offering New Clue on Cognitive Benefits A study published in Mechanisms of Ageing and Development has found that the senolytic combination of dasatinib and quercetin (D+Q) improved cognition in a mouse model of accelerated aging by reducing cholesterol production in astrocytes. Researchers identified the cholesterol biosynthesis pathway as the key mechanism, a finding they stated was not anticipated. Background on Cellular Senescence and Brain Aging As cells age, some stop dividing but do not undergo programmed cell death. These cells, known as senescent or “zombie cells,” accumulate in tissues…

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