The risk of developing dementia later in life is strongly predicted by a person's cognitive ability, functional limitations and physical health as many as 20 years before onset of the illness, according to a new RAND report. Related new research found that early detection of cognitive impairment helps people to take mitigating actions to prepare…

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease. A new study demonstrates that ketone bodies…

Study uncovers a polyphenol's mechanism in enhancing mitochondrial calcium uptake and muscle bioenergetics during aging. In a recent study published in the Cell Metabolism, a group of researchers explored mitochondrial calcium (mtCa²⁺) uptake in muscle aging and identified oleuropein as a mitochondrial calcium uniporter (MCU) activator to boost energy and performance. Background Mitochondrial…

How gut transit and pH shape the microbiome's role in metabolism and health, offering insights for personalized nutrition strategies. Study: Gut physiology and environment explain variations in human gut microbiome composition and metabolism. Image Credit: New Africa / Shutterstock In a recent study published in the journal Nature Microbiology, researchers investigated how…

Overcoming past challenges may require integrating traditional population science tools with innovative biomarker measures in a precision medicine framework. Study:  Diets to promote healthy brain ageing . Image Credit: Tatjana Baibakova / Shutterstock.com In a recent study published in Nature Reviews Neurology, researchers review the role of diet in…

Learning French while also developing language skills in one's mother tongue is no easy task. As a result, allophone children often face learning and communication difficulties in kindergarten, which can negatively impact their educational journey. However, solutions are emerging. According to a study led by Sylvana Côté, preschool education services significantly help bridge the gap…

Cognitive behavioral therapy (CBT) and a program of physical and mental rehabilitation probably improve symptoms of long covid, but the effects are modest, finds a review of the latest evidence published by The BMJ today. Intermittent aerobic exercise also probably improves physical function compared with continuous aerobic exercise. But the researchers found no compelling evidence to support the…

Factors beyond carbohydrates have a substantial influence on blood glucose levels meaning current automated insulin delivery systems miss vital information required for glucose regulation, a new study has found. A team of researchers from the University of Bristol analyzing automated insulin delivery data from people with Type 1 Diabetes (T1D) discovered that unexpected patterns in…

A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease – aortic stenosis (AS).  Published today in the peer-reviewed journal Annals of Medicine, the findings are believed to be the first to highlight this previously unrecognised…

If everyone in the United States population was as active as the top 25 per cent, individuals over the age of 40 could add five years to their life, according to a new study led by Griffith University researchers.  Physical activity has long been known to be good for health, however estimates have varied regarding…