Numerous treatment options for COVID-19 have been approved by the U.S. Food and Drug Administration over the last four years, including antiviral drugs and monoclonal antibodies that suppress an excessive immune response. Now, research from the Keck School of Medicine of USC has found that COVID-19 therapies cause few serious side effects, based on an…

Mass firings at the FDA have decimated divisions tasked with releasing public records generated by the agency's regulatory activities in sectors including tobacco, food, medical devices, and veterinary medicine. But as the dust settled on the layoff melee, a notable exception emerged among the agency's staff charged with responding to Freedom of Information Act requests.…

A study revealed that Jun13296, a novel PLpro inhibitor, demonstrates potent antiviral and anti-inflammatory effects in vivo, offering hope for future COVID-19 therapies beyond Paxlovid. Study:  Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates . Image Credit: Shutterstock AI Generator / Shutterstock.com A study recently published in…

A groundbreaking preclinical study reveals how targeting a viral enzyme with a new drug could prevent long-COVID complications, offering hope for millions and a powerful tool for future coronavirus threats. Study: A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID Over 77 million people globally have experienced…

Researchers have shown a new drug compound can prevent long COVID symptoms in mice – a landmark finding that could lead to a future treatment for the debilitating condition. The world-first study found mice treated with the antiviral compound, developed by a multidisciplinary research team at WEHI, were protected from long term brain and lung dysfunction –…

In today's interconnected world, infectious diseases pose an escalating threat, as demonstrated by the coronavirus pandemic and outbreaks of H1N1, SARS, Ebola, Zika, and H5N1 (bird flu) viruses-all of which have had significant global health and economic impacts. But more common viral diseases also contribute to global health challenges and economic costs. For example, seasonal…

Despite heightened obstetric risks, pregnant women may face a lower chance of developing Long COVID—findings that challenge assumptions and call for deeper insight into the immune landscape of pregnancy. Study: Long COVID after SARS-CoV-2 during pregnancy in the United States. Image Credit: Natalia Deriabina / Shutterstock In a recent study published in…

Despite a steady rate of race-related cardiac arrests, a major drop in deaths points to one life-saving solution: rapid CPR and defibrillation on the course. Study: Cardiac Arrest During Long-Distance Running Races. Image Credit: Pavel1964 / Shutterstock In a recent study published in the Journal of the American Medical Association, researchers examined…

Brazilian researchers reveal that even mild cases of COVID-19 can temporarily reduce heart rate variability, with stress on the autonomic nervous system lasting up to six months—especially in older individuals. Study:  Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group . Image Credit: Swetochka…

A new rapid review finds that full vaccination may reduce the odds of post-COVID-19 condition (PCC) by 27%, though more research is needed—especially in children and immunocompromised groups. Study:  Does COVID-19 vaccination reduce the risk and duration of post COVID-19 condition? Image Credit: KomootP/Shutterstock.com A recent rapid review published by…