Researchers identified three new compounds (caffaldehydes A, B and C) in roasted coffee beans that slow carbohydrate digestion more effectively than the diabetes drug acarbose. These compounds inhibit alpha-glucosidase, the enzyme that breaks down carbs into glucose, preventing blood sugar spikes. The compounds showed greater potency (IC?? as low as 17.50 µmol) compared to acarbose (45.07 µmol), suggesting a natural, side-effect-free alternative for glycemic control. Three additional trace diterpenes (magaric acid, octadecenoic acid, nonadecanoic acid) were also found to have similar benefits. Researchers used nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS/MS) to isolate these bioactive molecules efficiently. This method minimizes…
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