Chronic pain can persist long after an injury heals because the brain continues to send danger signals even in the absence of ongoing tissue damage, according to psychotherapist Christie Uipi. This phenomenon, known as neuroplastic pain, arises from the brain’s threat system remaining in alert mode, Uipi wrote in an article published April 12, 2026. Research cited by Uipi indicates that upward of 85 percent of chronic pain cases may be neuroplastic in nature, originating from faulty neural signaling rather than structural damage. Therapists say interventions such as Pain Reprocessing Therapy and self-directed techniques aim to interrupt the pain-fear cycle…
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