Pomegranate Compound Urolithin A Shown to Reduce Signs of Heart Failure in Early Lab Study A study published Aug. 19, 2026, in Science Advances reports that urolithin A, a compound linked to pomegranate consumption, reduced signs of heart failure with preserved ejection fraction, or HFpEF, in mice and improved relaxation in engineered human heart tissue. According to the research team, urolithin A activates the protein PKGI? by binding to the cysteine 42 site, a newly described mechanism that does not depend on nitric oxide. The authors cautioned that the findings are preclinical: urolithin A has not been tested or approved…
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