Autism has a strong genetic basis, driven by both rare, high-impact mutations and common, inherited gene variations. A single gene, SHANK3, can cause vastly different outcomes—from no autism to profound autism—depending on the number of copies a person has. Genetic research is paving the way for targeted treatments for severe, “profound” autism, including nutrient supplementation and gene-activating therapies. Genes are estimated to account for about 60% of autism risk, indicating environmental factors also play a significant role. The sharp rise in autism prevalence, especially in severe cases, suggests non-genetic factors are contributing to the increase. In a quiet household, three siblings shared the same…
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