The metabolic countdown: Scientists identify a critical window to halt accelerated brain aging Brain aging is not a steady decline but accelerates sharply during a “critical window” in midlife, typically between the ages of 40 and 60. The primary driver of this decline is neuronal insulin resistance, which prevents brain cells from efficiently using glucose for fuel. Ketones, an alternative fuel source, can bypass this insulin resistance and help stabilize brain networks when introduced during this critical period. Lifestyle interventions focused on metabolic health—such as diet, exercise and sleep—are most effective when implemented before significant neural damage occurs. This research underscores that future…
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