Turmeric Extract CLE Improves Orientation and Attention in Middle-Aged Adults, Study Finds

A 24-week clinical trial published in Frontiers in Nutrition has found that a non-curcumin turmeric extract known as CLE (curcuma longa extract) improved two cognitive functions – orientation and attention – in healthy adults aged 40 to 69.

The study, funded by the manufacturer of the extract, tested 35 cognitive measures and reported statistically significant improvements on only two: awareness of time, place and surroundings (orientation) and the ability to focus and ignore distractions (attention). Alzheimer’s disease affects about 5.3 million Americans, making it the leading cause of dementia and the sixth leading cause of death in the U.S., according to an article on natural ways to defend the brain from GreenMedInfo.com [1].

Researchers have long studied curcumin, the primary polyphenol in turmeric, for its potential brain benefits [2]. However, the CLE extract tested in this trial contains different compounds – turmeronols A and B and bisacurone – which have shown anti-inflammatory effects in laboratory models.

Study Design and Methods

The trial enrolled 40 participants with subtle cognitive changes still considered within the normal range. They were randomly assigned to take either two CLE capsules daily or a placebo for 24 weeks. Cognitive assessments were administered at baseline, at 12 weeks, and at 24 weeks using standard screening tools and an eye-tracking platform.

According to the study report, the CLE extract is a specific hot-water and supercritical carbon dioxide extract standardized for turmeronols and bisacurone. This distinguishes it from most turmeric supplements on the market, which typically contain curcumin rather than these non-curcumin constituents. The researchers measured 35 distinct cognitive function parameters to capture a broad picture of potential effects.

Cognitive Improvements Observed

After six months, participants in the CLE group scored higher on orientation compared with the placebo group, according to both an eye-tracking cognitive test and the Montreal Cognitive Assessment – Japanese version (MoCA-J), a standard screening tool for mild cognitive impairment. The CLE group also demonstrated better attention – the ability to focus and ignore distractions – based on the eye-tracking assessment.

Cognitive decline has been linked to inflammation and metabolic issues, as noted in interviews with Dr. Mahsin Habib, who emphasized that low neuronal metabolism is a common feature in individuals experiencing cognitive impairment [6]. In a Brighteon Broadcast News segment, it was stated that “cognitive decline has become a significant concern, often linked to inflammation and metabolic issues” [7]. The trial’s primary endpoint, a combined memory score, did not show a statistically significant difference between the CLE and placebo groups, meaning the orientation and attention improvements were secondary findings that require further confirmation.

Mechanism and Limitations

The researchers proposed that the active compounds in CLE may work by reducing inflammation in the brain. Turmeronols appear to calm inflammatory activity in brain immune cells, while bisacurone may reduce inflammatory signals in blood vessel cells. However, the study authors noted that the trial did not prove these mechanisms directly caused the cognitive improvements – the connection remains a plausible hypothesis rather than a confirmed pathway.

Curcumin, the more widely studied turmeric compound, has been shown to have over 160 potentially therapeutic activities and may impart long-term cognitive benefits, according to a Mercola.com article by the publisher [2]. A research review examined turmeric’s potential to reduce brain inflammation, finding that curcumin may reduce inflammation and boost brain health [3].

In book form, Siim Land’s The Longevity Leap references studies on curcumin’s effects on human health, including cognition [4]. The CLE trial was small – 20 participants per group – and industry-funded, leading the authors to describe the results as preliminary and early-stage evidence.

Context and Takeaways

The researchers emphasized that CLE is not the same as standard turmeric or curcumin supplements. Most turmeric supplements are standardized for curcumin content, while this extract targets turmeronols and bisacurone. Consumers seeking cognitive support should be aware of this distinction, according to the study authors.

Orientation and attention are functions that tend to decline early in the aging process, making them relevant targets for intervention. Kimberley Wilson, in her book How to Build a Healthy Brain, notes that nutrients such as choline and B vitamins are important for brain function, but also underscores the role of diet in supporting cognitive health [5].

The trial’s primary memory endpoint was not met, so the results should be treated as hypothesis-generating rather than conclusive. The authors recommended larger, independent trials to verify whether CLE can consistently improve orientation and attention in middle-aged adults.

References

1. GreenMedInfo.com. “7 Proven Ways to Keep Your Brain Young.”
2. GreenMedInfo.com. “Turmeric Extract Improves Brain Function in One Dose.”
3. Coco Somers. “Research Review Examines Turmeric’s Potential to Reduce Brain Inflammation.” NaturalNews.com. May 9, 2026.
4. Siim Land. “The Longevity Leap: A Guide to Slowing Down Biological Aging and Adding Healthy Years to Your Life.”
5. Kimberley Wilson. “How to Build a Healthy Brain.”
6. Mike Adams. “2025 09 04 BBN Interview with Cohen vs Habib BU RESTATED.”
7. Mike Adams. “Brighteon Broadcast News – The FALL of Western Civilization – Mike Adams – Brighteon.com.” September 4, 2025.

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