Lemongrass compound citronellal activates TRPV3 channels on the vagus nerve, triggering calcium influx and calming signals to the brainstem (cNTS), slowing heart rate and breathing. Study on stressed mice showed citronellal normalized heart rate, breathing and anxiety behaviors within minutes. The same TRPV3 channel also responds to sevoflurane (anesthetic) but binds at a different site—”vanilloid site” vs. “fenestration site.” Removing or blocking TRPV3 eliminated the calming effects of both citronellal and sevoflurane entirely. TRPV3 opens door for new anxiety drugs targeting the peripheral vagus nerve, bypassing the blood-brain barrier and avoiding addiction risks associated with current medications. Imagine this: You’re stressed.…
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