Vitamin D deficiency linked to increased oxidative stress and chronic disease risk Nearly 30% of U.S. adults are vitamin D deficient while 41% are insufficient, contributing to chronic diseases, immune dysfunction and higher mortality risks. Vitamin D regulates over 3,000 genes, impacting immunity, inflammation, bone health, and cognitive function. Deficiency disrupts thiol/disulfide homeostasis, increasing oxidative stress—a key driver of cellular damage. Studies show deficient individuals (<20 ng/mL) have higher disulfide levels (p<0.001) and worse antioxidant balance, worsening inflammation and disease risk. Osteoarthritis patients with low vitamin D (<30 ng/mL) exhibit higher oxidative stress markers and accelerated cartilage degradation. Vitamin D…
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