While pancreatic cancer rates are rising in people under age 50, a new survey conducted by The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) shows most people continue to believe that pancreatic disease affects only the elderly – and that there is nothing they can do to reduce their risk.

For this survey, respondents were asked about risk factors for pancreatic cancer. More than half (53%) of adults under age 50 said they would not recognize the early signs or symptoms of the disease, and more than one third (37%) believe there is nothing they can do to change their risk of pancreatic cancer. More than one third (33%) also believe only older adults are at risk.

Pancreatic cancer rates, however, have been rising by about 1% annually, and we are seeing this disease in people who are in their 40s much more regularly. This is a concerning trend, and one for which research is needed to learned why.”

Zobeida Cruz-Monserrate, PhD, co-leader of the OSUCCC – James Molecular Carcinogenesis and Chemoprevention Program

Risk factors you can and cannot change

Cruz-Monserrate says reducing risk for pancreatic cancer could start with maintaining a healthy weight. According to the National Institute of Diabetes and Digestive and Kidney Diseases, 1 in 3 Americans is overweight, and more than 2 in 5 are clinically obese. Obesity alone increases a person’s lifetime risk for pancreatic cancer by 20%.

On the flip side, the  American Cancer Society (ACS) estimates that just 10% of pancreatic cancers are linked to heredity risk (genetic markers passed down through families), including the BRCA genes, Lynch syndrome and others.

“You can’t change your genes, but you can change your lifestyle. For most people obesity is within someone’s power to change. It also increases a person’s risk for type 2 diabetes, other cancers and cardiovascular disease,” said Cruz-Monserrate.

More than 66,000 Americans will be diagnosed with pancreatic cancer in 2024, with less than 13% reaching five-years of survival, according to ACS estimates.

Other modifiable lifestyle factors believed to reduce your lifetime risk for pancreatic cancer include limiting or eliminating alcohol consumption, regular moderate exercise and a plant-based diet with limited red or processed meat.

More than half of survey respondents (54%) knew that genetic testing helps people understand if they should be screened for pancreatic cancer.

Research for screening, prevention and treatment

OSUCCC – James researchers are conducting studies to identify ways to screen for early signs of pancreatic cancer, including minimally invasive ways of screening pancreatic cysts, and understanding the roles of diabetes and chronic pancreatitis in pancreatic cancer risk. Until science provides more answers, however, Cruz-Monserrate says taking action to change lifestyle factors – especially maintaining a healthy weight – and understanding your family history are key for risk reduction.

“This disease is too often a silent killer, with no symptoms until it has progressed to less treatable stages. We must continue to aggressively pursue research that will help us prevent, diagnose and treat this disease more effectively,” said Cruz-Monserrate, who is conducting research on the prevention of obesity-related pancreatic cancer and on the impact of exercise on the development of this disease and pancreatitis.

To learn more about pancreatic cancer and research at the OSUCCC – James, visit cancer.osu.edu or call 1-800-293-5066.

Survey methodology

This study was conducted by SSRS on its Opinion Panel Omnibus platform. The SSRS Opinion Panel Omnibus is a national, twice-per-month, probability-based survey. Data collection was conducted from October 4 – October 7, 2024, among a sample of 1,004 respondents. The survey was conducted via web (n=974) and telephone (n=30) and administered in English. The margin of error for total respondents is +/-3.5 percentage points at the 95% confidence level. All SSRS Opinion Panel Omnibus data are weighted to represent the target population of U.S. adults ages 18 or older.